North American Academic Research

The monthly journal from TWASP 
Online ISSN: 1945-9098
Impact Factor : 3.75 (2023)


Volume: 3 Issue 3 [March 2020]


Article:Bacteriological profile and antibiotic sensitivity pattern of uropathogens in hemodialysis patients attending tertiary care hospital, Kathmandu, Nepal

Author: Abdul Karim Miya , Mehraj Ansari , Anil Dev Pant , Ganesh Rai , Kul Raj Rai, Shiba Kumar Rai


Volume: 3, Issue 3, March-2020
DOI: Nor. Am. Aca. Res. 2020 : 3(3) : 448-460: https://doi.org/10.5281/zenodo.3725002

Abstract: Hemodialysis (HD) patients are more susceptible to urinary tract infection (UTI) and UTIs are an important cause of morbidity and mortality in these patients. This study was conducted to find out the prevalence of UTI and multidrug-resistant (MDR) patterns of isolates among HD patients. A cross-sectional study was carried out from February 2018 to August 2018 at the National Kidney Center (NKC), Banasthali, Kathmandu. A total of 200 (108 male and 98 female) mid-stream urine samples were collected from patients with renal failure undergoing hemodialysis. Of them, 26% of samples showed significant bacteriuria. 22.2% and 30.4% of samples showed significant bacteriuria among males and females, respectively (p=0.19). Among the age-group, bacteriuria was ranked top at the age group >70 years (35.3.8%) followed by 51- 70 years (34.1%) (p=0.046). Nine different bacteria were isolated. Among them, the most predominant organism was Esch. coli (32.7%) followed by Staph. aureus (26.9%), Staph. saprophyticus (13.5%) and others. For the Gram-negative isolates, Imipenem (96.8%) was found to be the most effective drug followed by Amikacin (83.9%) and Cefepime (64.5%). For Grampositive isolates, Cefepime (76.1%) was found to be the most effective drug. The organisms showed 71.4% resistance to Cotrimoxazole and 57.1% resistance to Amoxicillin, Azithromycin, and Nitrofurantoin. The overall prevalence of MDR was found to be 57.7% in HD patients. Amikacin and Imipenem were found to be the drug of choice to treat UTI in HD patients. This study will be beneficial for making treatment policy and reducing the risk of UTI in HD patients.

Cite this article as: Abdul Karim Miya , Mehraj Ansari , Anil Dev Pant , Ganesh Rai , Kul Raj Rai, Shiba Kumar Rai;  Bacteriological profile and antibiotic sensitivity pattern of uropathogens in hemodialysis patients attending tertiary care hospital, Kathmandu, Nepal;  Nor. Am. Aca. Res. 2020 : 3(3) : 448-460: https://doi.org/10.5281/zenodo.3725002

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